Hydrophilic interaction liquid chromatography (HILIC) is able to separate from polar to highly polar solutes. using similar eluents to those in the reversed-phase mode (RPLC) and a polar stationary phase. where water is adsorbed onto its surface. It is widely accepted that multiple modes of interaction take place in the HILIC environment. https://www.freaknleather.com/product-category/specialty-smaw/